In the UK a LARGE proportion of dogs are what you call "mutts".. Crossbred and mongrel. They are largely the FIRST choice for a lot of people, and are MUCH loved and cherished. Not everyone wants a pedigree dog, I myself am not interested in owning one.
And as for the health side of things.... Well.. If we can talk science and genes here, "Mutts", being what they are - a MIX of dogs, breeds whatever, have a WIDER gene pool to choose from. Little fluffys ancestors are from far off and different places, so, the chances of 'that genetic disease' becomes watered down and so, LESS likely.
Pedigree dogs have a TINY gene pool to choose from... I'm sure if you followed every breed back to its origins they would all come from 2 original dogs (roughly).. So, the disease element is not watered down, therefore a LARGER risk.
Of course, that is not to say "Mutts" won't get an ailment or pedigrees will! It is just a case of looking at probabilities and "Mutts" win those stakes.
As for breeding them for money, I don't know about that here in the UK... If people want to pay, buy a pedigree... Most "Mutts" I know were not sold.