My neighbor's cocker spaniel has been given Advantage or Frontline monthly for a lot of her life. She has a real flea problem, they are constantly treating their whole place for fleas. Advantage and Frontline do not work any more. Her understanding from the vet is that the dog, not the fleas, has developed a resistance or immunity to the treatments. I don't know if this is correct or not. Can anyone enlighten me on this? I have used these products, mostly Frontline, only periodically if my dogs get fleas. They haven't had any in years, but they do get ticks this time of year. Frontline plus seems to help the ticks, but I don't want to overdo it.