I don't like leaving mine alone longer than 2 or 3 hours. Not because he makes a mess or pees/poos all over but because I feel badly leaving a puppy alone that long. They need tons of love, attention and socialization. If you're gone all the time they aren't getting these things.
Do you let him have free run of the house? If so, it's not a good idea. You'll end up with "accidents" all over the place. You must keep a constant eye on a puppy so they don't have accidents and go where you want them to go.
Mine have their own room at night (complete with love seat, crate and toys) and access to the hallway. The bathroom door gets shut and a baby gate put up to keep them out of the living room. Gunner still chews on everything. We're not worried about Tira, she's 2 y.o. and doesn't do anything wrong when left alone. But, instead of playing favorites, they both get blocked off at night. When we leave during the day Tira gets to stay in the living room and Gunner gets blocked off in the hallway/their room. Sometimes they will come into our room in the early morning hours (the door pushes open easily) and they'll jump on the bed and sleep with us til we get up (no accidents either).