Generic Heartguard / MDR1 gene question

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#1
has anyone ordered generic heartguard from here?:
http://www.petshed.com/products/category346.asp

am i safe ordering the generic?

second question, I have an aussie puppy and my breeder said she could have the MDR1 gene that causes problems when the dog gets ivermectin. but i've found something that says its ok to give the dogs with that gene mutation ivermectin because the dose isn't large enough:
"What heartworm prevention products can I use if my dog has the MDR1 mutation?

Fortunately, the dose of ivermectin, selamectin, milbemycin and moxidectin in the commercial heartworm preparations are low enough to be used safely even in dogs with the MDR1 mutation. It is only when the drugs are used at high doses, such as those used to treat mange (50 times higher dose than the heartworm prevention dose), that dogs with the mutation will develop neurological toxicity. Attempting to use large animal formulations of these drugs is likely to cause neurological toxicity because it is difficult to accurately measure "
source: http://www.vetmed.wsu.edu/depts-VCPL/FAQ.aspx

how does everyone feel about this? if you have a collie breed is it ok to give them this medicine?
 

Zoom

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#2
Stick with Interceptor. Works a little better and you don't have the MDR1 risk associated with it. It's what I use.
 

Tess32

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#3
No, do not give a dog that could have MDR1 invermectin products. When you have options, is it really worth risking death?
 

Jynx

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#8
I have an aussie who is mutant/mutant for the MDR1 gene, and no way would I even risk giving ivermectin to ANY aussie for that matter.

You'll find ALOT of vets don't have a clue about the MDR1 gene in aussies, mine was one of them. I printed all the info off the WSU website and gave them a list of no no drugs..Ivermectin is just ONE of the many you should avoid.

The amount of ivermectin in heartguard may very well be a low dose, but would you want to take the risk of killing your puppy?

Here are the links, and I HIGHLY recommmend you copy the info and give it to your vet.
http://www.vetmed.wsu.edu/depts-VCPL/
www.busteralert.org

Diane
 

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