Spook is our 9 year old English Setter we took home from the shelter last winter. Due to his back problems and barking, no one wanted him and if we hadn't taken him, he would have lost his life in a cold, dark shelter. This dog has truly made me in love with E. Setters, despite all his quirks. Six days ago he stopped eating and stopped walking. We thought it was his back again, But this time even when we increased his dose for his back, he was not eating and he did nothing but lay there, completely motionless. He went to the vet today and all I could find out from my sister was that he has elevated liver enzymes and WBC. He tested negative for heartworm(cheapest tests were run first, just to rule them out though we knew the likelihood of it being heartworm was zip.) He's being put on a home-cooked diet, and they are doing a Differential or CBC. I've been working at the clinic long enough to know when they start running all these expensive tests, it just isn't good, especially with the liver. I'm so worried he's in the beginning stages of liver disease or even cancer of some kind. So his total clinical signs are: lethargy anorexia increased thirst and urination weight loss pain in abdomen no recent bowel movements and some small amount of blood in his stool(which was just three little tiny squirts of diarrhea) about a week ago Anyone else ever had a dog with similar symptoms or can give me a clue of what more specifically may be going on. Elevated WBC and liver enzymes could mean so many things.