I've not tried it myself but I've known people who tried it, honestly I've never been very impressed with the results and everyone I've seen try it has ended up back on supplementation anyway. In my mind, there isn't much of a reason to do so. The medication isn't really a drug it's just... replacing absent thyroid hormone. Unless there's an allergy to an inert ingredient in a particular brand or the dose is incorrect, there really shouldn't be side effects. I've never really seen any cost advantage, either.