Clomicalm is specifically for animals. When he prescribed it, the vet told me the closest human approximation was Prozac. Since B was only going to be on it for a short period of time, I went with the vet script rather than ask about a human prescription. [Incidentally, however, Bailey is on a different prescription that I get from the drug store (Metronidazole).] I'm not saying that this vet is the be-all-and-end-all, but I enjoy this blog and found this recent entry interesting -- and on point for this discussion. Dolittler: Veterinary drugs, their off-label uses...and why some vet drugs cost so much ETA: a quick Google search suggests that Benedryl has sedative effects in dogs. Apparently nothing takes the edge off of mine other than lots of exercise.