I know it was probably a stupid idea to buy these, but we had given them to our farm dogs years ago and they seemed to like them. Anyways, my sister gave Maddie one for in her crate for the morning to keep her occupied for a bit after she had had her walk and morning food. I took her out and she had a normal poop and seemed to feel fine. I came back in and about a half hour later I noticed a huge loose diarrhea mass in my hallway. She hadn't looked like she was feeling sick at all. I looked at the ingredients and figure that must have caused it, there's nothing good in those treats and many of the ingredients are used as laxatives in people. I got rid of the rest of the ones I had. I know this was my fault and I should be more vigilant in what I let her eat and chew on. On the other hand, her Innova is really helping with her digestive system, so I'm glad that I figured out that her problem was caused by a stupid chew.