There is always a possibility of that. Just like its possible that Loki will have problems due to being spayed too early (spay incontinence and whatever else; I'm not a health expert). And her spay was about $150 with supplemental bloodwork. You can't win either way. But right now my intact nutter is in far better physical shape than my spayed girl. She seems far more likely to kill herself by jumping off a cliff than by getting any sort of less-exciting health problems.