If you read up on tick disease, it can cause all kinds of organ problems/failure if left untreated / chronic in humans and animals.
I have read up on tick disease, and I've consulted with veterinary infectious disease experts, including a veterinary nephrologist. Although they are not 100% understood, these diseases are NOT thought to generally act chronically in dogs as they do in people, and Lyme nephritis, if it exists, is thought to be an individual, idiosyncratic reaction that has absolutely nothing to do with whether or how long the animal was treated at an asymptomatic stage. That is, in an individual dog, either it's going to happen or it's not no matter what you do. And it happens in a fraction of those 5% of dogs who even show any clinical signs of tick borne disease at all.
To expound, it is thought to be the an individual animal's immune response that "clogs up" the filtering mechanism of the kidney with excessive numbers of antibody-antigen(Lyme organism) complexes, which are too large to be filtered. This starts a cascade of effects that ultimately damages the kidney.
The dog could not walk, stiff as a board, high fever, showing clinical signs came on overnite. Bloodwork showed elevated liver enzymes, low blood count which indicates infection, Snap positive for anaplasmosis. All other testing (including xrays/ultrasound) showed 'nothing', put her on a course of doxy, retested in 2 months all bloodwork back in normal range. Granted this could have been a "phantom" thing, (I tend to have dogs who 'get' phantom illnesses on occasion) but all points to anaplasmosis.
No, all does not point to anaplasmosis. All points to a dog with liver disease that also tested positive for anaplasmosis, which is extremely likely in a tick-borne disease endemic area. Just because the dog tested positive for anaplasmosis, it doesn't mean the anaplasmosis caused the symptoms.
Was the liver biopsied? There are many, many things that can cause acute hepatitis. There has never been a reported case of tick borne disease causing liver disease in a dog to my knowledge, maybe your vet should write that case up and submit it to a journal.
As for the liver issues being lepto, no it wasn't.
Did you have negative paired titers?
I suppose we can go back and forth on this till the cows come home..I trust my vet's knowledge and when they tell me they see dogs going straight into liver failure and dying with no clinical signs of tick disease tho the dogs are testing positive for it, I tend to believe them.
I trust my vet's knowledge, too, since she's me. Unfortunately, there are a lot of vets out there who mis-use the 4DX test. It is NOT an appropriate screening test. That is, it is NOT meant to be used to test every dog, every year and then put the dogs who test positive on antibiotics. It is meant to be used to look for antibodies in a dog showing appropriate clinical signs. I have spoken to multiple infectious disease experts who hold this opinion and they uniformly, across the board recommend NOT treating a dog who tests positive without clinical signs (ie "don't treat a blue dot").
For awhile several years ago we were using the 4DX tests for our heartworm tests, and I can't even tell you how many dogs tested positive for one of the three tick borne diseases without having any signs. We did not routinely put those dogs on antibiotics (although we always gave the owners the option) and several years out I can tell you that not ONE of those dogs has ever developed any problems.
This particular issue makes me peevey because 1. I hate, hate, hate correlation being confused with causation and 2. I don't care for large scale misuse of antibiotics when there is no real evidence to do so 3. There is so much misunderstanding of these diseases floating around.
/rant