Radiodense material is easily seen on radiographs of the GI tract in animals with zinc-containing foreign bodies. Changes in the CBC, chemistry profile, urinalysis, and coagulation profile reflect the degree of toxicity to various organ systems. The hemogram typically reveals a regenerative hemolytic anemia characterized by changes in erythrocyte morphology. The leukogram often shows a neutrophilic leukocytosis secondary to stress, pancreatitis, and a regenerative bone marrow. Serum chemistry changes that are seen secondary to hepatic damage include elevations in bilirubin, the transaminases, and alkaline phosphatase. As zinc accumulates in the pancreas, increases in amylase and lipase can be seen following pancreatitis and pancreatic necrosis. Glomerular damage and renal tubular epithelial necrosis result in elevations in BUN, creatinine, amylase, and urine protein. Hemoglobinuria can be differentiated from hematuria during urinalysis; the urine color will not clear after centrifugation in the presence of hemoglobinuria. Prolongation of prothrombin time and activated partial thromboplastin time can result from toxic effects on the synthesis or function of coagulation factors.